论文部分内容阅读
目的 探讨IL 1α在IgAN肾组织中的表达与疾病进展的关系 .方法 对 3 6例经光镜、免疫荧光、电镜等病理诊断为IgAN的肾组织进行了IL 1α免疫组织化学检测 .结果 IL 1α主要表达于肾小管上皮细胞内 (近曲小管 3 1/3 6;远曲小管 2 5 /3 6) .在肾小球的毛细血管腔内侧 (15 /3 6)和肾小球靠球囊壁的肾小囊腔 (10 /3 6)亦可见IL 1α的表达。在肾小球系膜区无明显增宽时 ,IL 1α的表达率高 .结论 IL 1α在IgAN肾组织内主要位于肾小管上皮细胞内 .在IgAN的进展过程中 ,IL 1α的表达率增强 ,此期如选用IL 1α受体拮抗剂进行治疗 ,可控制IgAN的进展 .
Objective To investigate the relationship between the expression of IL-1α in IgAN and the progression of the disease.Methods IL-1α immunohistochemistry was performed in 36 renal tissues of 36 cases diagnosed as IgAN by light microscopy, immunofluorescence and electron microscopy.Results IL 1α Mainly expressed in the renal tubular epithelial cells (proximal convoluted tubules 3 1/3 6; distal convoluted tubules 25/36) .In the glomerular capillary lumen (15/36) and the glomerular by balloon The wall of the renal capsule (10/36) also shows the expression of IL-1α. IL 1α was highly expressed in glomerular mesangial area.Conclusion IL 1α is mainly located in renal tubular epithelial cells in IgAN renal tissue.Ig 1α expression is enhanced during the progress of IgAN, This period if the choice of IL 1α receptor antagonists for treatment, can control the progress of IgAN.