目的:综述莫达非尼对抗飞行员睡眠剥夺，提高飞行操作能力的应用效果，为开展飞行员服用精神类药物对抗睡眠剥夺、提高飞行操作能力的研究提供参考。资料来源与选择:国内外该领域的相关文献资料。资料引用:国内外公开发表的期刊论文及科技报告35篇。资料综合:简要回顾睡眠剥夺对飞行员觉醒度、认知能力和飞行操作能力的不利影响，总结睡眠剥夺飞行员服用莫达非尼后模拟飞行操作能力的改善情况。在战时、跨时区及长航飞行时，飞行员因睡眠剥夺导致其觉醒度下降、注意力和记忆力等认知能力降低，从而飞行操作能力受到影响。莫达非尼能有效降低睡眠剥夺条件下飞行员的疲劳程度、保持其中枢觉醒度，同时作为认知增强剂能显著改善睡眠剥夺飞行员的认知能力，降低睡眠剥夺对飞行员模拟飞行操纵能力的影响。结论:飞行员合理服用莫达非尼是保持警觉性、降低疲劳程度、提高认知能力、维持飞行操作能力的重要应急性措施。进一步开展使用中枢神经系统药物对抗飞行员睡眠剥夺，维持其飞行操作能力的研究对提高我军航空卫生保障能力具有重要意义。“,”Objective:To conduct the research progress on applying Modafinil to modify the sleep deprivation and provide reference to the further research on improving sleep deprived pilot′s flight ability by taking psychotropic medications.Literature resource and selection:Relevant articles and scientific reports published in China and abroad.Literature quotation:Thirty-five published papers were cited.Literature synthesis:The negative effects of sleep deprivation on pilots′ alertness, cognitive function, and flight operation ability were briefly reviewed in this article, and the improvement in the flight operation ability of sleep deprived pilots by taking Modafinil verified by the computer-simulated flight was summarized. In wartime, pilots suffered from the decline of alertness, impairment of such cognitive functions as concentration and memory and degenerative flight operation ability caused by sleep deprivation in cross time zone and long-distance flights. Modafinil can effectively alleviate the fatigue of pilots under sleep deprivation, sustain their central nervous alertness, significantly improve their cognitive function as a cognitive enhancer, and reduce the influences on pilot′s operation ability that caused by sleep deprivation in simulated flight.Conclusions:The rational use of Modafinil is an important emergency measure to sustain pilot′s alertness, alleviate fatigue and improve cognitive ability, as well as to maintain his flight operation ability. The further research on resisting sleep deprivation by psychotropic medications to maintain flight operation ability would be of great significance to the improvement on Chinese military medical support.