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目的:为了解我院药物不良反应(ADR)的规律及特点,发挥临床药师在ADR监测工作及合理用药中的作用。方法:对我院2011年收集到的295例ADR报告分别从患者情况、ADR级别、报告人、使用药品分类、给药途径及临床表现等项目进行统计分析。结果:295例ADR中,新的严重的ADR占23.05%(68例);临床药师上报的ADR占27.46%(81例);老年患者引发的ADR居多,占33.90%。抗菌药物引起的ADR居首位,占46.10%(136例),其次为中药制剂,占12.54%(37例);主要的ADR类型为皮肤及其附件损害,占49.83%(146例),其次为消化系统损害;给药途径以静脉给药引起的最多,占75.93%(224例)。结论:临床药师应协助医生做好合理用药工作,重视抗菌药物的临床应用管理,减少和避免ADR的发生。
Objective: To understand the rules and characteristics of adverse drug reactions (ADR) in our hospital and to play the role of clinical pharmacists in ADR monitoring and rational drug use. Methods: A total of 295 ADR cases collected in our hospital in 2011 were analyzed statistically from the patient’s condition, ADR level, the reporter, the use of drug classification, route of administration and clinical manifestations. Results: Of the 295 ADRs, 23.05% (68 cases) were serious new ADRs; 27.46% (81 cases) reported ADRs by clinical pharmacists; and 33.90% were ADRs caused by elderly patients. ADR caused by antimicrobial drugs ranked first, accounting for 46.10% (136 cases), followed by traditional Chinese medicine preparations, accounting for 12.54% (37 cases); the main types of ADR were skin and its accessories, accounting for 49.83% (146 cases) For the digestive system damage; route of administration to intravenous administration caused the most, accounting for 75.93% (224 cases). Conclusion: Clinical pharmacists should assist doctors to make rational use of drugs, attach importance to the clinical application of antimicrobial agents, reduce and avoid the occurrence of ADR.