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目的 观察系统性红斑狼疮(systemic lupus erythematosus,SLE)中抗心磷脂抗体( anticardiolipin antibodies,ACA)的阳性率及与临床关 系,以及免疫抑制剂对ACA滴度的影响。方法用酶 联免疫吸附法(ELISA)的ACAIg含量测定药盒,作血清ACA含量测定。 对17例SLE患者入院及治疗3个月后行ACA滴度对比。结果 ACAIgG、ACAIgA、ACAIgM阳性率分别为:62.1%、5 2.9%、35.6%。ACAIgG、ACAIgM测定值与代表SLE活动性的病情积 分呈正相关;ACAIgG、ACAIgA、ACAIgM与补体C_3呈负相关;A CAI gG与 补体C_4呈负相关。并发血栓时,ACAIgA增高;并发狼疮脑病时,ACAIgG、 ACAIgM测定值比无此并发症者明显增高。17例SLE患者治疗3月后,ACA滴度 显著下降。结论SLE的ACA测定值与病情活动性 有关 ;并发血栓时,ACAIgA增高;并发狼疮脑病时,ACAIgG、ACAIgM测定值 增高。经免疫抑制剂治疗3月后,ACA滴度显著下降。
Objective To investigate the positive rate of anticardiolipin antibodies (ACA) in systemic lupus erythematosus (SLE) and their clinical significance, and the effect of immunosuppressive agents on the titer of ACA. Methods The kit of enzyme-linked immunosorbent assay (ELISA) was used to determine the content of ACA in serum. 17 cases of SLE patients hospitalized and treated 3 months after ACA titer comparison. Results The positive rates of ACAIgG, ACAIgA and ACAIgM were 62.1%, 59.9% and 35.6% respectively. The values of ACAIgG and ACAIgM were positively correlated with the scores of SLE activity. ACAIgG, ACAIgA and ACAIgM were negatively correlated with complement C_3. A CAI gG was negatively correlated with complement C_4. Accompanied by thrombosis, ACAIgA increased; concurrent lupus encephalopathy, ACAIgG, ACAIgM measured values were significantly higher than without such complications. Seventeen patients with SLE treated for 3 months, ACA titer decreased significantly. Conclusions The ACA value of SLE is related to the activity of the disease. When the thrombosis is complicated by thrombosis, the ACAIgA is increased. When the patients with lupus encephalopathy are complicated, the measured values of ACAIgG and ACAIgM increase. After 3 months of immunosuppressant treatment, ACA titers dropped significantly.