目的观察腹腔镜术后加用内美通治疗子宫内膜异位症的临床疗效、不良反应及停药后对妊娠率、复发率的影响。方法77例经腹腔镜手术确诊为子宫内膜异位症的患者,随机分为2组:达那唑组39例,口服达那唑200mg,2次/d;内美通组38例,口服内美通2.5mg,2次/周,两组均连续用药3个月。观察并比较两组临床症状、体征、用药后的副作用及停药后1年内症状复发率和妊娠率等变化。结果两组症状、体征缓解率相似,均较治疗前明显改善(P<0.01);内美通组体重增加、痤疮、肝功能损害、潮热、阴道干燥和异常出血等不良反应发生率明显低于达那唑组(P<0.05)。停药后,内美通组排卵和月经平均恢复时间较达那唑组短(P<0.05);1年内达那唑组不育症患者的累积妊娠率为52.63%,内美通组为58.97%,两组比较差异无统计学意义(P>0.05);1年内达那唑组和内美通组症状和体征复发情况相似,两组比较差异无统计学意义(P>0.05)。结论腹腔镜手术后加用内美通可有效控制子宫内膜异位症患者症状,提高不孕患者的妊娠机会,且副作用小、服用方便,值得临床推广应用。 Objective To observe the clinical efficacy, adverse reactions and the effects on the pregnancy rate and recurrence rate after laparoscopic surgery plus endometriosis treatment of endometriosis. Methods A total of 77 patients with endometriosis diagnosed by laparoscopic surgery were randomly divided into two groups: 39 in the danazol group, 200 mg in the danazol group, and 2 in the propofol group; Within the United States through 2.5mg, 2 times / week, two groups were continuous medication for 3 months. The clinical symptoms and signs, the side effects after treatment and the changes of symptoms and pregnancy rate within one year after stopping were observed and compared. Results The symptom and symptom relief rate of both groups were similar, which were significantly improved compared with that before treatment (P <0.01). The incidence of adverse reactions such as body weight gain, acne, liver damage, hot flashes, vaginal dryness and abnormal bleeding were significantly lower In the danazol group (P <0.05). After stopping the drug, the ovulation and menstruation recovery rate of the patients in the Naometong group were shorter than those in the danazol group (P <0.05). The cumulative pregnancy rate was 52.63% in the danazol group and 58.97 in the Naitertong group % Respectively. There was no significant difference between the two groups (P> 0.05). The recurrences of symptoms and signs were similar in the danazol group and the control group within 1 year. There was no significant difference between the two groups (P> 0.05). Conclusions After laparoscopic surgery, the use of Promethazone can effectively control the symptoms of patients with endometriosis and improve the pregnancy chances of infertile patients. The side effects are small and convenient to take, which is worthy of clinical application.