对豚鼠进行静脉注射不同剂量的利尿酸、速尿、丁尿胺后观察听神经动作电位、耳蜗血管纹及Corti氏器毛细胞形态学的改变。随着用药剂量的增大,AP振幅下降,三种利尿剂对内耳超微结构的毒性作用基本相似,病损主要在血管纹的边缘细胞及中间细胞,外毛细胞次之。实验证实三种利尿剂均具耳毒作用。文中对三种袢利尿剂的耳毒作用机制进行了探讨与比较。 The guinea pigs were intravenously injected with different doses of uric acid, furosemide and bupivacaine to observe the changes of the auditory nerve action potentials, cochlear stria vascularis and Cortihaber’s hair cell morphology. With the increase of the dose, the AP amplitude decreased. The three diuretics had similar toxic effects on the ultrastructure of the inner ear. The lesion was mainly located on the marginal cells and middle cells of vascular pattern, followed by the outer hair cells. The experiment confirmed that all three diuretics have ototoxicity. In this paper, three kinds of 袢 diuretics ototoxicity mechanism were discussed and compared.