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目的:探讨氧化低密度脂蛋白(ox-LDL)、高敏C反应蛋白(hs-CRP)与经皮冠状动脉介入治疗(PCI)术后支架内再狭窄的相关性。方法:45例患者PCI术后6~12个月内接受冠状动脉造影复查,其中18例有再狭窄作为再狭窄组,27例无再狭窄作为对照组。2组术后均接受阿司匹林、波立维、他汀类等药物治疗。取2组患者PCI术前、后冠状动脉造影复查时血浆标本,采用酶联免疫吸附法(ELISA)检测血浆ox-LDL水平,超敏免疫比浊法检测血浆hs-CRP水平,酶法测定血脂水平。结果:①再狭窄组PCI术后ox-LDL、hs-CRP水平较术前均明显升高[(1.32±0.35)∶(0.53±0.17)mg/L、(4.82±1.44)∶(3.50±1.18)mg/L],均P<0.01;对照组PCI后ox-LDL、hs-CRP水平较术前明显下降[(0.32±0.13)∶(0.55±0.13)mg/L、(2.28±0.71)∶(3.37±1.25)mg/L],均P<0.05。②再狭窄组和对照组PCI术前ox-LDL、hs-CRP水平差异无统计学意义,再狭窄组PCI术后ox-LDL、hs-CRP水平显著高于对照组(均P<0.01)。③再狭窄组和对照组术后TC、TG、LDL-C水平均较术前明显下降(P<0.05),但2组间PCI术前和术后比较均差异无统计学意义(P>0.05)。④再狭窄组和对照组术前、术后ox-LDL和hs-CRP水平均呈正相关。结论:PCI术后再狭窄患者血浆ox-LDL及CRP水平明显升高,二者可作为PCI术后再狭窄的预测指标。
Objective: To investigate the relationship between ox-LDL, hs-CRP and in-stent restenosis after percutaneous coronary intervention (PCI). METHODS: Forty-five patients underwent coronary angiography within 6-12 months after PCI. Of these, 18 had restenosis as a restenosis group and 27 had no restenosis as a control group. The patients in both groups received aspirin, beryl, statins and other drugs after operation. Plasma samples were taken from two groups before PCI and after coronary angiography. Plasma ox-LDL levels were measured by enzyme-linked immunosorbent assay (ELISA), hs-CRP levels by hypersensitivity turbidimetry, Level. Results: ① The levels of ox-LDL and hs-CRP in restenosis group were significantly higher than those before surgery [(1.32 ± 0.35) :( 0.53 ± 0.17) mg / L, (4.82 ± 1.44) :( 3.50 ± 1.18 (P <0.01). The levels of ox-LDL and hs-CRP in the control group after PCI were significantly lower than those before the operation (0.32 ± 0.13 vs 0.55 ± 0.13 mg / L, (3.37 ± 1.25) mg / L], all P <0.05. ② The levels of ox-LDL and hs-CRP in restenosis group and control group before PCI were not statistically different. The levels of ox-LDL and hs-CRP in restenosis group were significantly higher than those in control group (all P <0.01). ③ The levels of TC, TG and LDL-C in the restenosis group and the control group were significantly lower than those before the operation (P <0.05), but there was no significant difference between before and after PCI in the two groups (P> 0.05 ). ④ The levels of ox-LDL and hs-CRP in restenosis group and control group were positively correlated before and after surgery. Conclusion: The levels of plasma ox-LDL and CRP in patients with restenosis after PCI are significantly increased, both of which can be used as predictors of restenosis after PCI.