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介绍经鼻脑靶向理论及其制剂的研发现状,为开发中药鼻腔脑靶向药物提供依据。以经鼻给药、鼻腔给药、脑靶向等关键词检索中英文文献51篇。通过解释鼻腔生理结构的特点,分析药物经鼻脑靶向转运的作用机制,介绍了经鼻脑靶向治疗中枢神经系统疾病的应用实例;通过了解经鼻给药新型制剂(原位凝胶、脂质体、微球、纳米粒制剂),并结合中药鼻疗法,阐述了我国中药现有经鼻制剂的应用及开发中药脑靶向制剂的可能途径,认为中药经鼻给药脑靶向制剂具有广阔开发前景。
This article introduces the research status of nasal brain targeting theory and its preparation and provides the basis for the development of CNS-targeted brain-targeting drugs. 51 Chinese and English literatures were searched by using nasal administration, nasal administration and brain targeting. By explaining the characteristics of nasal physiological structure, the mechanism of drug targeting and transport through the nasal brain was analyzed. The application of nasal and brain targeting treatment of central nervous system diseases was introduced. By understanding the nasal administration of new agents (in situ gel, Liposomes, microspheres and nanoparticle preparations). Combined with Chinese medicine nasal therapy, this paper expounds the application of nasal preparations in traditional Chinese medicine and the possible ways of developing traditional Chinese medicine brain-targeting preparations. Has broad development prospects.