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目的观察缬沙坦治疗慢性心力衰竭病人的临床疗效。方法选择82例慢性充血性心力衰竭病人,心功能Ⅱ~Ⅳ级,随机分为两组,一组加用缬沙坦,另一组采用常规治疗方法,治疗4个月。结果治疗后,观察组左室射血分数(LVEF)、6m in步行试验均明显提高(P<0.01);对照组左室射血分数(LVEF)无明显改变,6m in步行试验有所提高(P>0.05)。观察组左室收缩(LVS)、舒张末期内径(LVD)明显缩小(P<0.01),对照组无明显改变(P>0.05)。结论缬沙坦治疗慢性心力衰竭疗效肯定,和ACE抑制剂一样目前均为心力衰竭治疗中的重要药物。
Objective To observe the clinical efficacy of valsartan in patients with chronic heart failure. Methods Eighty-two patients with chronic congestive heart failure were enrolled. Patients with heart failure were divided into two groups randomly. One group received valsartan and the other group received conventional therapy for 4 months. Results After LVEF and 6m in walking test, the left ventricular ejection fraction (LVEF) in the observation group was significantly increased (P <0.01); the left ventricular ejection fraction (LVEF) P> 0.05). The left ventricular systolic pressure (LVS) and end diastolic diameter (LVD) in the observation group were significantly reduced (P <0.01), but there was no significant change in the control group (P> 0.05). Conclusions Valsartan is effective in treating chronic heart failure. Like ACE inhibitors, valsartan is currently an important drug in the treatment of heart failure.