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膀胱肿瘤是我国泌尿系统最常见的恶性肿瘤,绝大多数(90%以上)是移行细胞癌,超过70%的移行细胞癌(TCC)在治疗后复发,复发肿瘤中约10%～15%出现恶性程度增加。如果能够明确引起膀胱癌复发的机制,预测膀胱癌复发,将会改进患者的治疗情况。Hedgehog信号通路在胚胎发育中起着重要的作用,控制着细胞的增殖与命运[1]。近年来人们发现许多疾病都与这个信号通路有关。当这个信号通路异常激活时,会引起肿瘤的发生与发展。本文就Patched/hedgehog信号通路与膀胱肿瘤的关系作一综述。
Bladder cancer is the most common malignant tumor in urinary system in our country. Most of them (more than 90%) are transitional cell carcinoma. More than 70% of transitional cell carcinoma (TCC) relapse after treatment, and about 10% to 15% of recurrent tumors appear Malignancy increased. If you can clearly cause the mechanism of bladder cancer recurrence, predict the recurrence of bladder cancer, will improve the patient’s treatment. Hedgehog signaling plays an important role in embryonic development, controlling the proliferation and fate of cells [1]. In recent years, people have found that many diseases are related to this signaling pathway. When this signal pathway is abnormally activated, it will cause the occurrence and development of tumors. This article reviews the relationship between the Patched / hedgehog signaling pathway and bladder tumors.