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目的 研究p2 7kip1在胃癌中的表达及其与胃癌临床病理因素的关系 ,了解p2 7kip1在胃癌进展中的作用。方法 用免疫组化方法检测 40例胃癌组织中p2 7kip1和cyclinE的表达 ,所有数据用卡方检验。结果 40例胃癌组织中有 2 5例 (6 2 5 % )p2 7kip1蛋白表达阴性 ,在弥漫型癌、肿瘤穿透浆膜、淋巴结转移阳性以及Ⅲ、Ⅳ期胃癌中p2 7kip1的表达显著降低 (P <0 0 5 )。在cyclinE阳性的胃癌中p2 7kip1阳性率显著低于cyclinE阴性胃癌的p2 7kip1阳性率 (16 7%vs 5 4 5 % ,P <0 0 5 )。结论 p2 7kip1在胃癌中的表达下降促进肿瘤的进展 ,是肿瘤高度恶性的标志。
Objective To investigate the expression of p2 7kip1 in gastric cancer and its relationship with clinicopathological factors in gastric cancer and to investigate the role of p2 7kip1 in the progression of gastric cancer. Methods The expressions of p27kip1 and cyclinE in 40 cases of gastric carcinoma were detected by immunohistochemistry. All data were analyzed by chi square test. Results The expression of p2 7kip1 in 25 cases (62.5%) of 40 cases of gastric carcinoma was negative. The expression of p27kip1 was significantly lower in diffuse carcinoma, tumor-penetrating serosal membrane, lymph node metastasis positive and stage Ⅲ, Ⅳ gastric carcinoma P <0 0 5). The positive rate of p27kip1 in cyclinE-positive gastric cancer was significantly lower than that of cyclinE-negative gastric cancer (16.7% vs 54.5%, P <0.05). Conclusion The decreased expression of p2 7kip1 in gastric cancer promotes tumor progression and is a marker of highly malignant tumors.