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目的:制备龙血竭结肠定位片,并评价其体外释药情况。方法:制备龙血竭含药片芯,采用HPMC,EC与丙烯酸Ⅱ号树脂等制备龙血竭结肠定位片。单因素试验考察药物释放的影响因素,确立处方组成,采用正交设计对包衣液处方进行优化。结果:最佳包衣处方为溶胀层增重3%,肠溶层增重2%,丙烯酸Ⅱ号树脂与EC比值1∶10,结肠定位片的时滞6 h,时滞5 h后累积释药达80%。结论:龙血竭结肠定位片在体外具有结肠定位释放的特性,能达到治疗结肠部位疾病的目的。
Objective: To prepare Longxuexuan colon positioning tablets, and to evaluate the drug release in vitro. Methods: The preparation of Dragon’s Blood tablets containing drug tablets, the use of HPMC, EC and acrylic resin No. 2 Preparation of Dragon’s blood colon colon positioning tablets. Single factor test to study the influencing factors of drug release, the establishment of prescription composition, the orthogonal design to optimize the coating liquid prescription. Results: The optimal coating prescriptions were 3% weight gain of swelling layer, 2% weight gain in enteric layer, 1: 10 ratio of acrylic resin to EC, 6 h delay in colon positioning and 5 h delay in cumulative release Drug up to 80%. Conclusion: DRG colon positioning tablets have the characteristics of colon-specific release in vitro and can achieve the purpose of treating diseases in the colon.