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基因表达是一个受多因素调控的复杂过程。组蛋白是染色体的基本结构——核小体中的一个重要组成部分,其在N末端氨基酸残基上发生的乙酰化、甲基化、磷酸化、泛素化、多聚ADP糖基化等多种共价修饰作用。其改变染色质状态,使转录因子与组蛋白或DNA相互作用发生变化,从而发挥基因调控作用。神经系统中特异性的组蛋白修饰已经在多种神经系统疾病发病机制的解释及新型治疗方案的研究中得到应用。
Gene expression is a complex process regulated by many factors. Histones are the basic structure of chromosomes - an important part of nucleosomes that undergoes acetylation, methylation, phosphorylation, ubiquitination, poly-ADP-glycosylation, etc. at the N-terminal amino acid residues A variety of covalent modification. It changes the chromatin state, the transcription factor and histone or DNA interaction changes, which play a gene regulatory role. Specific histone modifications in the nervous system have been used in the explanation of the pathogenesis of a number of neurological diseases and in the study of novel therapeutic regimens.