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短链脂肪酸(short-chain fatty acid,SCFA)是肠道菌群代谢产物中最主要的标志物之一。肠道中不同种属类型的细菌产生的SCFA的种类和数量各不相同,通过检测肠道中SCFA的变化,可以反应肠道中肠道菌群的变化。过敏性疾病患儿在早期与正常儿童肠道中的肠道菌群有明显差异,故SCFA的种类和数量也表现出明显的差异。有研究显示过敏性疾病患儿肠道中丙酸、异丁酸、丁酸、异戊酸、戊酸的水平较正常儿童低,而乙酸和异己酸的水平则较高。开展这方面的研究,对于探索肠道菌群及其代谢产物与过敏性疾病发病机制的关系有十分重要的意义。
Short-chain fatty acid (SCFA) is one of the most important markers of intestinal flora metabolites. Different types of bacteria in the gut produce different types and amounts of SCFAs, and changes in intestinal gut flora can be detected by detecting changes in the intestinal SCFAs. Children with allergic diseases in early and normal intestinal flora of intestinal bacteria were significantly different, so the type and number of SCFA also showed significant differences. Studies have shown that children with allergic diseases intestinal propionic acid, isobutyric acid, butyric acid, isovaleric acid, valeric acid levels lower than normal children, while the level of acetic acid and isocaproic acid is higher. To carry out this research is very important for exploring the relationship between intestinal flora and its metabolites and the pathogenesis of allergic diseases.