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目的:探讨肿瘤转移相关基因1(MTA1)蛋白表达与食管鳞癌临床病理参数之间的关系。方法:应用免疫组化SP法和Western blotting方法检测50例食管鳞癌组织中MTA1蛋白的表达。结果:50例食管鳞癌组织中42例MTA1蛋白阳性表达,阳性率为84%。而癌旁组织中10例MTA1蛋白阳性表达,阳性率为20%,差异有显著性(P<0.05);MTA1高表达与组织分化程度和淋巴结转移有关(P<0.05),与年龄、性别、肿瘤大小无关(P>0.05)。结论:MTA1在食管鳞癌中高表达,与食管鳞癌的疾病进展密切相关,并有望成为基因治疗的新靶点。
Objective: To investigate the relationship between the expression of metastasis-associated gene 1 (MTA1) and clinicopathological parameters in esophageal squamous cell carcinoma. Methods: Immunohistochemical SP method and Western blotting were used to detect the expression of MTA1 protein in 50 cases of esophageal squamous cell carcinoma. Results: Forty-two cases of MTA1 protein in 50 cases of esophageal squamous cell carcinoma were positive, the positive rate was 84%. The positive expression rate of MTA1 was 10% in the paracancerous tissues (P <0.05). The high expression of MTA1 was correlated with the degree of differentiation and lymph node metastasis (P <0.05), but not with age, sex, Tumor size has nothing to do (P> 0.05). Conclusion: MTA1 is overexpressed in esophageal squamous cell carcinoma, which is closely related to the progress of esophageal squamous cell carcinoma and is expected to become a new target of gene therapy.