研究表明,内皮屏障功能丧失是急性炎症的标志,并且在严重感染中促成器官功能衰竭,但是目前还没有关于内皮屏障功能稳定性治疗方面的研究。内源性肽肾上腺髓质素(Adrenomedullin,AM)血清水平显示其在严重感染包括脓毒症和脓毒性休克时升高,在体内和体外脓毒症模型中用作有效的内皮屏障功能的稳定剂。AM还具有心血管保护作用,包括在炎症状态保护微循环。总之,AM可能作为一个有效的保护因素,通过保护内皮屏障功能防治严重感染中的心血管功能障碍。 Studies have shown that loss of endothelial barrier function is a hallmark of acute inflammation and contributes to organ failure in severe infections, but there are currently no studies on the treatment of endothelial barrier function stability. Serum levels of the endogenous peptide, adrenomedullin (AM), have been shown to increase with severe infections, including sepsis and septic shock, and serve as a stabilizing function of effective endothelial barrier function in vivo and in vitro in sepsis models Agent. AM also has cardiovascular protection, including protection of the microcirculation in inflammatory conditions. In conclusion, AM may serve as an effective protective factor against cardiovascular dysfunction in severe infections by protecting the endothelial barrier function.