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目的 针对诊断多发性硬化 (MS)的 Mc Donald标准、Poser标准的有效性做比较。方法 按中枢神经系统 (CNS)受累的临床表现将 3 5例 MS患者分为脊髓型和非脊髓型两个亚组 ,并对部分患者进行了随访观察 ,用卡方检验对两种诊断标准进行比较分析。结果 两种诊断标准对脊髓型、非脊髓型 MS的诊断阳性率接近 (P>0 .0 5) ,但 Mc Donald标准中诊断不能的例数相对较多 (P<0 .0 5) ,经随访观察均证实为 MS。结论 Poser标准对MS诊断的有效性优于 Mc Donald标准 ,但对其在诊断进展型 MS时的病程规定有待于进行改良或者灵活运用
Purpose To compare McDonald’s criteria for diagnosing multiple sclerosis (MS) and Poser criteria. Methods According to the clinical manifestations of central nervous system (CNS) involvement, 35 patients with MS were divided into two subgroups, spinal cord type and non-spinal cord type. Follow-up observation was performed on some patients. Two diagnostic criteria comparative analysis. Results The positive diagnostic rates of the two diagnostic criteria for spinal cord and non-spinal cord MS were close (P> 0.05). However, the McDonald criteria for diagnosis were not able to diagnose more cases (P <0.05) Follow-up were confirmed as MS. Conclusions Poser standard is superior to Mc Donald standard in diagnosis of MS, but the course of its diagnosis in advanced MS needs to be improved or flexibly used