恶性贫血是由于胃粘膜不能分泌适量的内因子以确保维生素B_(12)在回肠远端的肠内吸收。维生素B_(12)是合成脱氧核糖核酸的主要原料。恶性贫血时脱氧核糖核酸的合成发生了变化,从而延迟了细胞分裂,于是在骨髓内发生了巨幼红细胞增生,幼红细胞核成熟不佳和巨多分叶核白细胞等;末梢血液中的细胞数量随之减少。初期恶性贫血的临床表现是多样性的,但在进行阶段则少变化。在患病期间都有舌 Pernicious anemia is due to the inability of gastric mucosa to secrete an appropriate amount of intrinsic factor to ensure the absorption of vitamin B_(12) in the intestines distal to the ileum. Vitamin B_(12) is the main raw material for synthesizing DNA. The synthesis of deoxyribonucleic acid changes in pernicious anemia, which delays cell division. Thus, in the bone marrow, giant erythropoietin hyperplasia, poor maturation of erythroblasts, and giant multilobulated nucleus leukocytes occur; the number of cells in the peripheral blood The reduction. The clinical manifestations of pernicious anemia in the early days are diverse, but change little during the initial phase. Have tongue during illness