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血吸虫病是一种流行广泛、严重危害人类健康和社会经济发展的人兽共患寄生虫病。我国是日本血吸虫病流行最严重的国家之一。宿主感染血吸虫后虫卵沉积于肝脏,引起机体免疫应答,导致以淋巴细胞、嗜酸性粒细胞和巨噬细胞浸润为主要特征的肝脏虫卵肉芽肿病变,该慢性炎症过程最终会引起肝纤维化并出现腹水、肝脾肿大等临床表现。本文将从血吸虫病肝纤维化病理学特征、肝纤维化的形成与调节、重要的炎症因子及信号通路、nc RNA在血吸虫病肝纤维中的调控作用以及抗纤维化治疗和新药研究等几个方面进行综述。
Schistosomiasis is a zoonotic parasitic disease that is widespread and seriously endangering human health and socio-economic development. Our country is one of the countries with the most serious epidemic of schistosomiasis japan. After the host infect Schistosoma japonicum, the eggs deposit in the liver, causing the body’s immune response, leading to the liver worm egg granulomatosis characterized by infiltration of lymphocytes, eosinophils and macrophages, which eventually leads to liver fibrosis And ascites, hepatosplenomegaly and other clinical manifestations. This article will schistosomiasis pathological features of liver fibrosis, the formation and regulation of liver fibrosis, important inflammatory factors and signaling pathways, ncRNA in schistosomiasis liver fibrosis regulation and anti-fibrosis treatment and new drug research Aspects to review.