A series of aza-naphthindolizinedione derivatives, such as indolizinoquinolinedione derivatives, indolizinophthalazinedionederivatives and indolizinoquinoxalinedione derivatives were designed and synthesized. The synthetic pathway was also proposed.2008 Lin Kun An. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.