论文部分内容阅读
组成型光形态建成蛋白1(COP1)于多种类型肿瘤中过度表达,在促进细胞增殖、转化和肿瘤进展等多种生物学过程中起重要的作用。COP1与p53呈负调节并参与致癌基因Jun激酶的信号通路。目前COP1表达在人类肿瘤发生、发展中的具体作用仍存在许多争论,通过解析COP1与p53和Jun激酶的相互关联,进一步探讨与肿瘤的侵袭及转移关系。
Constitutive light morphogenetic protein 1 (COP1) is overexpressed in many types of tumors and plays an important role in a variety of biological processes that promote cell proliferation, transformation, and tumor progression. COP1 and p53 are negatively regulated and are involved in the oncogene Jun kinase signaling pathway. At present, there are still many controversies about the specific role of COP1 expression in the development and progression of human tumors. By analyzing the correlation between COP1 and p53 and Jun kinases, we further explore the relationship between the expression of COP1 and tumor invasion and metastasis.