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目的:观察慢性肾小球疾病内皮素(ET)及一氧化氮(NO)改变。方法:采用放免法和比色法测定血浆及尿ET和NO含量。结果:慢性肾小球肾炎(CGN)和肾病综合征(NS)血浆及尿ET、NO均显著高于健康人(P＜0.01)。慢性肾衰血浆及尿ET显著增高,但NO显著低于肾功能正常组(P＜0.01),有高血压患者血浆及尿NO明显低于血压正常患者(P＜0.01)。结论:各型肾小球疾病均有ET和NO异常,ET增高及NO降低与肾功能衰竭及肾脏病高血压有密切关系。
Objective: To observe the changes of endothelin (ET) and nitric oxide (NO) in chronic glomerular disease. Methods: Radioimmunoassay and colorimetry were used to determine plasma and urine ET and NO levels. Results: Plasma and urinary ET and NO in patients with chronic glomerulonephritis (CGN) and nephrotic syndrome (NS) were significantly higher than those in healthy controls (P <0.01). The levels of plasma and urinary ET in patients with chronic renal failure were significantly higher than those in patients with normal renal function (P <0.01). The plasma and urine NO in patients with hypertension were significantly lower than those in patients with normal blood pressure (P <0.01). Conclusion: There are abnormal ET and NO in all kinds of glomerular diseases. The increase of ET and the decrease of NO are closely related with renal failure and hypertension of kidney disease.