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CD4+CD25+Foxp3Treg调节性T细胞(Treg)具有维持自身免疫耐受和调节免疫应答的功能,其功能紊乱或数目下降是导致自身免疫性疾病的重要原因之一。许多研究证实,Foxp3在调控CD4+CD25+Foxp3Treg细胞的发育和功能上起着重要作用。近年来发现,CD4+CD25+Foxp3Treg在再生障碍性贫血疾病的发病过程中,存在着数量和功能的异常,是否能将CD4+CD25+Foxp3Treg在再生障碍性贫血中数量和功能的异常作为再生障碍性贫血与其他临床症状与再生障碍性贫血相似,目前实验手段难以鉴别的疾病区分开来,本文就对此作一综述。
CD4 + CD25 + Foxp3Treg regulatory T cells (Tregs) have the function of maintaining autoimmune tolerance and modulating immune response. One of the important reasons leading to autoimmune diseases is their dysfunction or number decline. Many studies confirm that Foxp3 plays an important role in the regulation of the development and function of CD4 + CD25 + Foxp3 Treg cells. In recent years, found that CD4 + CD25 + Foxp3Treg in the pathogenesis of aplastic anemia, the existence of quantitative and functional abnormalities, whether the number of CD4 + CD25 + Foxp3Treg in aplastic anemia and dysfunction as aplastic anemia Anemia and other clinical symptoms and aplastic anemia similar to the current experimental methods are difficult to distinguish between diseases identified in this article to make a review.