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目的探讨血尿素氮(BUN)水平与冠状动脉介入治疗后造影剂肾病发生的相关性。方法 120例行冠状动脉造影及冠状动脉支架置入术的患者,均应用低渗非离子型造影剂碘佛醇进行造影,按照BUN指标分为BUN升高组(39例)和BUN正常组(81例)。分析两组治疗后BUN、血肌酐(Cre)值及造影剂肾病的发生率。结果 BUN正常组手术前后BUN及Cre值比较差异均无统计学意义(P>0.05);BUN升高组术前BUN及Cre值均明显低于术后(P<0.05)。BUN正常组造影肾病发病率为1.23%,明显低于BUN升高组的10.26%(P<0.05)。结论单纯BUN升高与冠状动脉支架置入术后造影剂肾病的发生具有明显相关性。
Objective To investigate the correlation between blood urea nitrogen (BUN) level and contrast-induced nephropathy after coronary intervention. Methods A total of 120 patients undergoing coronary angiography and coronary stenting were enrolled in this study with low-osmolality non-ionic contrast agent, ioversol, and were divided into BUN group (39 cases) and BUN group 81 cases). The BUN, serum creatinine (Cre) and the incidence of contrast-induced nephropathy were compared between the two groups after treatment. Results There was no significant difference in the BUN and Cre between the normal BUN group and the normal BUN group (P> 0.05). The BUN and Cre values in the elevated BUN group were significantly lower than those before operation (P <0.05). The incidence of contrast-induced nephropathy in the normal BUN group was 1.23%, significantly lower than that in the BUN-elevated group (10.26%, P <0.05). Conclusions The elevation of simple BUN has obvious correlation with the occurrence of contrast agent nephropathy after coronary stent implantation.