为了解我国食品中单核细胞增生李斯特菌(Listeriamonocytogenes,Lm)药物敏感性的状况,为我国食源性单核细胞增生李斯特菌耐药性监测提供基线资料。对2003及2004年全国食品污染物监测网11省(市)分离的142株Lm,采用E-test法对13种抗生素进行药物敏感性试验。142株Lm的平均耐药率为14·1%,主要耐受四环素、强力霉素、红霉素和链霉素。其中,对四环素耐受最严重,耐药率达13·4%。7类食品中自生鸡肉中分离的菌株耐药率最高,达28·3%。11省市中,来自河南、北京和吉林的菌株耐药率居前三位,分别为37·5%,26·3%,25·0%。监测结果表明我国食品中的Lm存在耐药株,分离自不同食品、不同省份的Lm耐药性存在差异。 In order to understand the drug susceptibility of Listeria monocytogenes (Lm) in our country, we provided the baseline data for monitoring the Listeria monocytogenes resistance in our country. 142 strains of Lm isolated from 11 provinces (municipalities) of China National Food Pollutant Monitoring Network in 2003 and 2004 were tested for drug sensitivity by E-test on 13 antibiotics. The average resistance rate of 142 strains of Lm was 14.1%, which was mainly resistant to tetracycline, doxycycline, erythromycin and streptomycin. Among them, tetracycline was the most tolerant, with drug resistance rate of 13.4%. Among the seven kinds of food, the strains isolated from the raw chicken had the highest resistance rate of 28.3%. Among the 11 provinces and municipalities, the top three strains of drug-resistant strains from Henan, Beijing and Jilin were 37.5%, 26.3% and 25.0% respectively. The monitoring results showed that Lm in Chinese food had resistant strains isolated from different foodstuffs, and Lm resistance in different provinces was different.