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尽管已广泛应用孕激素抑制子宫内膜生长,但其分子机制尚未完全明了。原癌基因c-fos,作为一种核相关蛋白是雌激素诱导子宫内膜增殖的介质之一。体外研究表明,醋酸安宫黄体酮(MPA)能通过刺激催乳激素(PRL)释放使子宫内膜间质细胞蜕膜化。 为了探讨月经周期及MPA对人体子宫内膜中原癌基因c-fos和PRL表达的影响,应用双盲、随机、对照试验方法,选取37例有规律月经周期的健康妇女,根据其月经周期
Although progestin has been widely used to inhibit endometrial growth, its molecular mechanism is not fully understood. Proto-oncogene c-fos, as a nuclear-related protein, is one of the mediators of estrogen-induced endometrial proliferation. In vitro studies have shown that progesterone acetate progesterone (MPA) can decay endometrial stromal cells by stimulating the release of prolactin (PRL). In order to investigate the effects of menstrual cycle and MPA on the expression of protooncogene c-fos and PRL in human endometrium, 37 healthy women with regular menstrual cycle were selected by double-blind, randomized and controlled trial. According to their menstrual cycle