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为了研究抗生素对疑有羊膜炎和长期破膜的妊娠妇女的治疗作用,作者用两种头孢菌素给予一次剂量后,测定母体血清、羊水和脐带血清中的药物浓度,以观察它们的动力学作用。共60例健康妊娠妇女,妊娠38～40周,均为剖腹产。30例给予吡硫头孢菌素1克肌肉注射;30例给予头孢菌素Ⅳ1克口服。除取母体血清测定外,剖腹产时取羊水和脐带血清检查。研究结果表明母体血清中吡硫头孢菌素浓度的峰值出现在用药后30分钟,而头孢菌素Ⅳ是一小时,头孢菌素Ⅳ的平均峰值明显高于吡硫头孢菌素(P<0.001)。羊水和脐带
In order to investigate the therapeutic effect of antibiotics on pregnant women with suspected amniotic inflammation and long-term rupture of membranes, the authors measured the drug concentrations in maternal serum, amniotic fluid and umbilical cord serum after one dose with two cephalosporins to observe their kinetics effect. A total of 60 healthy pregnant women, 38 to 40 weeks of pregnancy, are caesarean section. Thirty cases were given Pyrethroides cephalosporin 1 gram intramuscular injection; 30 cases were given cephalosporin Ⅳ 1 gram orally. In addition to take maternal serum determination, cesarean section to take amniotic fluid and cord blood serum check. The results showed that peak concentrations of pyrethroid cephalosporin in maternal serum occurred 30 minutes after drug administration, whereas cephalosporin IV was one hour. The average peak value of cephalosporin IV was significantly higher than that of pyrethrin (P <0.001) . Amniotic fluid and umbilical cord