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目的探讨胺碘酮联合美托洛尔治疗慢性心功能不全(CHF)合并室性心律失常的临床效果。方法选取河南省直第二医院56例CHF合并室性心律失常患者,按随机数表法分为对照组和实验组各28例,对照组单独使用胺碘酮治疗,实验组应用胺碘酮+美托洛尔治疗,比较两组治疗效果。结果实验组心功能改善情况、心律失常总有效率明显优于对照组(P<0.05);实验组心血管事件发生率明显低于对照组(P<0.05);两组药物不良反应发生率比较,差异无统计学意义(P>0.05)。结论应用胺碘酮+美托洛尔治疗CHF合并室性心律失常效果显著,不良反应少。
Objective To investigate the clinical effect of amiodarone combined with metoprolol in the treatment of chronic heart failure (CHF) complicated with ventricular arrhythmia. Methods Fifty-six patients with CHF complicated with ventricular arrhythmias in Henan No.2 Straight Hospital were divided into control group and experimental group according to random number table method, 28 cases in each group. The control group was treated with amiodarone alone. The experimental group was treated with amiodarone + Metoprolol treatment, the treatment effect of two groups were compared. Results The improvement of cardiac function and the total effective rate of arrhythmia in experimental group were significantly better than those in control group (P <0.05). The incidence of cardiovascular events in experimental group was significantly lower than that in control group (P <0.05). The incidence of adverse drug reactions , The difference was not statistically significant (P> 0.05). Conclusions The application of amiodarone + metoprolol in the treatment of CHF with ventricular arrhythmia is effective and has few adverse reactions.