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目的探讨新生儿呼吸衰竭发病相关的影响因素。方法对2007年7月至2008年6月本院新生儿重症监护病房收治的呼吸衰竭患儿和非呼吸衰竭患儿资料进行回顾性分析,比较两组患儿的临床特征。结果研究期间共收治新生儿839例,入选病例组188例,对照组190例。病例组患儿母亲居住农村、剖宫产、多胎妊娠、早产、妊娠并发症、宫内窘迫的发生率高于对照组,差异有统计学意义(P<0.05)。引起新生儿呼吸衰竭的主要原发病中,病例组胎粪吸入综合征(OR=6.409)、羊水吸入性肺炎(OR=4.880)、呼吸窘迫综合征(OR=16.450)、缺氧缺血性脑病(OR=2.205)、出生窒息(OR=2.355)和先天性心脏病(OR=2.394)比例多于对照组,差异有统计学意义(P均<0.05)。结论居住地、母亲孕期情况、胎粪吸入综合征、羊水吸入性肺炎、呼吸窘迫综合征、缺氧缺血性脑病、出生窒息、先天性心脏病是本次新生儿呼吸衰竭调查的主要影响因素。
Objective To investigate the influencing factors of neonatal respiratory failure. Methods The data of children with respiratory failure and non-respiratory failure admitted to neonatal intensive care unit in our hospital from July 2007 to June 2008 were retrospectively analyzed. The clinical features of the two groups were compared. Results A total of 839 newborns were enrolled during the study period, 188 cases were enrolled in the case group and 190 cases in the control group. The incidence of cesarean section, multiple pregnancy, premature delivery, pregnancy complications and intrauterine distress in the case group was higher than that in the control group (P <0.05). In the main primary diseases causing neonatal respiratory failure, case meconium aspiration syndrome (OR = 6.409), amniotic fluid aspiration pneumonia (OR = 4.880), respiratory distress syndrome (OR = 16.450), hypoxic-ischemic The incidence of asphyxia (OR = 2.355) and congenital heart disease (OR = 2.394) in encephalopathy group (OR = 2.205) was higher than that in control group (P all <0.05). Conclusions The main factors influencing the neonatal respiratory failure were the place of residence, maternal pregnancy, meconium aspiration syndrome, amniotic fluid aspiration pneumonia, respiratory distress syndrome, hypoxic-ischemic encephalopathy, birth asphyxia and congenital heart disease .