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本文报道2例以重症肝炎和严重溶血性贫血为特征的EB病毒(Epstein-Barr virus,简称EBV)感染。其年龄分别为2岁及6岁。临床表现无持续发热,血中未找到异型淋巴细胞。1例死于肝功能衰竭。另1例在恢复期作肝活检示肝细胞点状坏死伴单核细胞浸润。血清间接免疫荧光试验抗-EB病毒荚膜抗原IgM抗体(IgM antibodies to viral capsid antigen,简称抗-VCA IgM)阳性,疱疹病毒抗体阴性,乙肝病毒标志物(HBVM)阴性。
This article reports 2 cases of Epstein-Barr virus (EBV) infection characterized by severe hepatitis and severe hemolytic anemia. Their age is 2 years old and 6 years old respectively. No clinical manifestations of persistent fever, abnormal blood cells not found in lymphocytes. One patient died of liver failure. Another case of liver biopsy in the recovery phase showed dot-like hepatocyte necrosis with mononuclear cell infiltration. Serum indirect immunofluorescence tests were positive for anti-EB viral capsid antigen (IgM antibodies), negative for herpesvirus antibodies and negative for hepatitis B virus markers (HBVMs).