目的:观察痰热清注射液联合利巴韦林治疗手足口病患儿的临床疗效。方法:将150例手足口病患儿作为研究对象,根据治疗方法不同分为治疗组(n=80)和对照组(n=70),两组患儿均给予相同支持疗法,酌情使用抗菌和解热药物。对照组给予利巴韦林10~15mg·kg-1加5%葡萄糖注射液100mL静脉滴注,根据病情纠正水、电解质紊乱;治疗组在对照组基础上给予痰热清注射液0.5mL·kg-1加5%葡萄糖注射液100mL静脉滴注。若患儿合并有感染,给予头孢呋辛30~100mg·kg-1静脉滴注,观察两组患儿治疗效果。结果:经治疗,治疗组患儿咽痛消退时间、热退时间、手足皮疹消退时间分别为(3.10±1.32)、(2.20±0.50)、(3.35±1.08)天,对照组患儿咽痛消退时间、热退时间手、足皮疹消退时间分别为(3.45±2.08)、(2.47±1.26)、(3.70±1.51)天,差异均无统计学意义(P均>0.05);治疗组总有效率为97.5%,明显高于对照组的88.6%,差异有统计学意义(P<0.05)。结论:采用痰热清注射液联合利巴韦林等辅助治疗儿童手足口病疗效确切,无明显毒副作用,值得临床推广应用。 Objective: To observe the clinical effect of Tanreqing injection and ribavirin in treating children with hand-foot-mouth disease. Methods: 150 children with HFMD were enrolled in this study. The patients were divided into treatment group (n = 80) and control group (n = 70) according to different treatment methods. Both groups were given the same supportive therapy, Hot drugs. The control group was given ribavirin 10 ~ 15mg · kg-1 plus 5% glucose injection 100mL intravenous infusion, according to the disease to correct water and electrolyte disorders; treatment group on the basis of the control group was given Tanreqing injection 0.5mL · kg -1 plus 5% glucose injection 100mL intravenous infusion. If children with infection, given cefuroxime 30 ~ 100mg · kg-1 intravenous infusion, the treatment effect of two groups were observed. Results: After treatment, the time of pharyngodynia, the retreat time and hand-foot-skin rash in the treatment group were (3.10 ± 1.32), (2.20 ± 0.50) and (3.35 ± 1.08) days, respectively. (3.45 ± 2.08), (2.47 ± 1.26) and (3.70 ± 1.51) days, respectively, with no significant difference between the two groups (P> 0.05). The total effective rate Was 97.5%, which was significantly higher than that of the control group (88.6%), the difference was statistically significant (P <0.05). Conclusion: Tanreqing injection combined with ribavirin and other adjuvant treatment of children with hand, foot and mouth disease curative effect is exact, no obvious side effects, is worthy of clinical application.