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目的 :探讨头面中线非何杰金淋巴瘤 (中线NHL)的临床病理特点及免疫表型。方法 :采用免疫组化LSAB法 ,选用单克隆抗体CK、LCA、UCHL1、L2 6检测 2 8例中线NHL ,4例鼻咽癌(NPC)和 2例坏死性鼻腔炎的组织表型抗原。结果 :2 8例中线NHL中 ,2 7例阳性表达LCA(白细胞共同抗原 ) ;2 0例 (71.4 % )UCHL1阳性 ,为T细胞淋巴瘤 ;8例 (2 8.6 % )L2 6阳性 ,为B细胞淋巴瘤。无 1例表达CK(Cytokeratin ,细胞角蛋白抗原 )。 4例NPC中的肿瘤细胞均表现较强的CK阳性而LCA呈阴性。 2例坏死性鼻腔炎及NPC的病灶中可见一些散在的细胞呈现LCA、UCHL1、L2 6阳性。结论 :中线NHL以T细胞淋巴瘤多见。
Objective: To investigate the clinicopathological characteristics and immunophenotypes of the midline non-Hodgkin’s lymphoma (midline NHL). Methods: Immunohistochemical LSAB method was used to detect the tissue phenotypic antigens of 28 cases of midline NHL, 4 cases of nasopharyngeal carcinoma (NPC) and 2 cases of necrotizing nasalis by using monoclonal antibodies CK, LCA, UCHL1 and L2 6. RESULTS: Twenty-seven cases of midline NHL had LCA (leukocyte common antigen) positive, 20 cases (71.4%) of UCHL1 positive, T cell lymphoma, and 8 (22.6%) L2 6 positive were B Cell lymphoma. None of the cases expressed CK (Cytokeratin, cytokeratin antigen). The tumor cells in 4 NPC showed strong CK positive and LCA negative. 2 cases of necrotizing nasal inflammation and NPC lesions showed some scattered cells showed LCA, UCHL1, L2 6 positive. Conclusion: The midline NHL is more common in T-cell lymphoma.