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目的探讨吗啡缓释片治疗晚期癌痛的疗效及不良反应。方法 98例晚期癌痛患者给予吗啡缓释片进行治疗,最初用药剂量为每12h 10mg或20mg,可根据患者情况适当调整剂量。结果治疗后总有效率为83.7%,治愈率为59.2%,有效率为24.5%,显效率为10.2%,无效率为6.1%;对神经痛的治疗作用最为明显,总有效率为81.8%。主要不良反应为便秘、恶心、呕吐,经对症治疗均缓解且无成瘾性。结论盐酸吗啡缓释片治疗晚期癌痛临床效果较好,安全可行,值得临床推广。
Objective To investigate the efficacy and adverse reactions of morphine sustained-release tablets in the treatment of advanced cancer pain. Methods Ninety-eight patients with advanced cancer pain were given morphine sustained-release tablets for treatment. The initial dose was 10 mg or 20 mg every 12 hours, and the dosage could be adjusted according to the patient’s condition. Results After treatment, the total effective rate was 83.7%, the cure rate was 59.2%, the effective rate was 24.5%, the markedly effective rate was 10.2% and the ineffective rate was 6.1%. The most effective treatment for neuralgia was the total effective rate was 81.8%. The main adverse reactions were constipation, nausea, vomiting, symptomatic treatment were relieved and no addiction. Conclusion Morphine hydrochloride sustained-release tablets for the treatment of advanced cancer pain is better, safe and feasible, worthy of clinical promotion.