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目的探讨奥美拉唑联合六味能消胶囊治疗反流性食管炎的临床疗效。方法选择2008年9月到2009年10月我院收治的反流性食管炎患者86例,随机分为对照组和治疗组各43例,对照组给予西药奥美拉唑单独治疗;治疗组在对照组基础上给予六味能消胶囊治疗,两组均治疗10周后,比较临床疗效和不良反应;随访1年,比较复发情况。结果治疗组的显效率为62.8%,有效率为90.7%明显高于对照组的53.5%和71.1%(P<0.05);随访后,治疗组复发率明显低于对照组(P<0.01);两组不良反应发生率比较差异无统计学意义(P>0.05)。结论奥美拉唑综合联合六味能消胶囊治疗反流性食管炎疗效确切,不良反应小,且复发率低,值得在临床中推广应用。
Objective To investigate the clinical efficacy of omeprazole combined with Liuwei Nengxiao capsule in the treatment of reflux esophagitis. Methods Seventy-six patients with reflux esophagitis admitted to our hospital from September 2008 to October 2009 were randomly divided into control group and treatment group (n = 43), and control group received western omeprazole alone (n = The control group was given Liuwei Nengxiao capsule treatment, both groups were treated for 10 weeks, the clinical efficacy and adverse reactions were compared; follow-up of 1 year, the recurrence was compared. Results The effective rate of the treatment group was 62.8%, the effective rate was 90.7%, which was significantly higher than that of the control group (53.5% vs 71.1%, P <0.05). After the follow - up, the recurrence rate of the treatment group was significantly lower than that of the control group (P <0.01). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusions Omeprazole combined with Liuwei Nengxiao Capsule is effective in treating reflux esophagitis with small adverse reactions and low recurrence rate. It is worth to be popularized in clinic.