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目的:研究新药喘平滴丸的平喘、镇咳、祛痰作用。方法:采用组胺-乙酰胆碱引喘法、卵清蛋白致敏法、肺溢流实验法、豚鼠气管螺旋条法、豚鼠肺条法、小鼠氨水及枸橼酸引咳法和小鼠酚红祛痰法考察平喘滴丸的平喘镇咳祛痰作用。结果:喘平滴丸能显著延长组胺-乙酰胆碱诱发豚鼠哮喘反应的潜伏期;显著降低卵清蛋白致敏豚鼠哮喘的反应级并延长其引喘潜伏期;显著抑制由组胺引起的豚鼠肺溢流量增加;减轻组胺引起的豚鼠离体气管平滑肌和肺条收缩;减少氨水及枸橼酸引发小鼠咳嗽反应次数;增加小鼠气管内酚红排泌量。结论:喘平滴丸具有一定的平喘、镇咳、祛痰的功效。
Objective: To study the antiasthmatic, antitussive and expectorant effects of the new drug asthma pill. Methods: The histamine - acetylcholine asthma method, ovalbumin sensitization method, lung overflow test method, guinea pig tracheal spiral strip method, guinea pig lung strip method, mouse ammonia and citric acid cough method and mouse phenol red Expectorant method Pingchuan drop pills asthma antitussive expectorant effect. Results: Chuan Pills can significantly prolong the incubation period of histamine-acetylcholine-induced asthma in guinea pigs, significantly reduce the reaction grade of ovalbumin-sensitized guinea pig asthma and prolong the latent period of asthma, significantly inhibit the histamine-induced guinea pig lung overflow Increase; reduce histamine-induced guinea pig tracheal smooth muscle and lung contraction; reduce ammonia and citric acid-induced mouse cough response times; increased mouse tracheal phenol red excretion. Conclusion: Chuanping dripping pill has a certain asthma, antitussive, expectorant effect.