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目的:研究IL-18基因编码区105位点多态性与冠心病遗传易感性的关系。方法:采用多聚酶链反应限制性片段长度多态性分析法检测162例冠心病患者和134例对照者IL-18基因编码区105位点基因型,分析其与冠心病易感性的关系。结果:IL-18基因编码区105位点多态性中AA、AC、CC3种基因型在冠心病组和对照组中的频率分别为70.4%、29.0%、0.6%和88.1%、11.9%、0%。AC基因型患者患冠心病风险为AA基因型者的3.041倍(95%CI1.631～5.669),C等位基因携带者发生冠心病的风险是A等位基因携带者的2.806倍(95%CI1.556～5.061)(均P<0.01)。结论:IL-18基因编码区105位点多态性与福建地区部分汉族人群冠心病的发生存在相关性,携带AC、CC基因型人群发生冠心病风险较高。
Objective: To study the relationship between polymorphism of IL-18 gene coding site 105 and genetic predisposition of coronary heart disease. Methods: The genotypes of 105 loci encoding IL-18 gene in 162 patients with CHD and 134 controls were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The relationship between them and susceptibility to coronary heart disease was analyzed. Results: The frequencies of AA, AC and CC genotypes in the 105 locus of the IL-18 gene coding region were 70.4%, 29.0%, 0.6% and 88.1%, 11.9% in the CHD group and the control group respectively. 0%. Patients with AC genotype had a 3.041-fold risk of coronary heart disease (95% CI, 6.631-5.669), and a 2.806-fold (95% CI) risk of coronary heart disease in carriers of the C allele CI 1.556 ~ 5.061) (all P <0.01). CONCLUSION: The polymorphism of IL-18 gene coding site 105 is associated with the occurrence of coronary heart disease in some Han nationality in Fujian province. The incidence of coronary heart disease is higher in people with AC and CC genotypes.