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目的分析BP与T2DM患者尿白蛋白/肌酐(UACR)的关系,探讨BP对糖尿病慢性肾脏疾病(CKD)的影响。方法收集330例T2DM患者资料,测BP和UACR。根据UACR水平分为<30mg/24h组、30~299mg/24h组和≥300mg/24h组,检测各组BP及UACR等水平的变化情况。结果正常血压组及高血压组蛋白尿发生率为31.4%及64.2%。病程<10年、病程10~20年及病程>20年正常血压者与高血压者比较,总蛋白尿的发生率分别为0%、8%,7.6%、30.1%,0%及51.7%(P<0.01)。UACR<30mg/24h组、≥300mg/24h组高血压发生率为30.3%及69.1%;病程<10年、病程10~20年及病程>20年患者中<30mg/24h组、30~299mg/24h组和≥300mg/24h组比较,高血压发生率分别为28.9%、67.4%、100%,33.3%、50.9%、76.7%,25.0%、84.6%和100%(P<0.01)。结论高血压加速CKD的发生。
Objective To analyze the relationship between urinary albumin / creatinine (UACR) in patients with T2DM and the effects of BP on chronic kidney disease (CKD). Methods The data of 330 patients with T2DM were collected and measured for BP and UACR. According to the level of UACR, they were divided into <30mg / 24h group, 30 ~ 299mg / 24h group and> 300mg / 24h group. The levels of BP and UACR in each group were detected. Results The incidence of proteinuria in normotensive and hypertensive groups was 31.4% and 64.2% respectively. The overall incidence of total proteinuria was 0%, 8%, 7.6%, 30.1%, 0%, and 51.7%, respectively, in patients with normal blood pressure <10 years, duration of 10 to 20 years and duration of disease> 20 years P <0.01). UACR <30mg / 24h group,> 300mg / 24h group the incidence of hypertension was 30.3% and 69.1%; duration of <10 years, duration of 10 to 20 years and duration of 20 years of patients <30mg / 24h group, 30 ~ 299mg / The prevalence of hypertension was 28.9%, 67.4%, 100%, 33.3%, 50.9%, 76.7%, 25.0%, 84.6% and 100%, respectively (P <0.01) in 24h group and ≥300mg / 24h group. Conclusion Hypertension accelerates the occurrence of CKD.