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血清脂蛋白(α)浓度是由基因决定的,很少受年龄、性别、营养或环境因素如药物、食入限制的影响。为了探讨脂蛋白(α)在缺血性中风,尤其是年轻患者发病病因上的作用。作者采用先进的酶联免疫吸附法,测定了101例缺血性中风慢性期患者和37例健康对照组的血清脂蛋白(α)浓度。并结合中风类型和发病年龄进行研究。101例患者中,动脉血栓性中风66例(男44例,女22例,平均年龄60±12岁,平均病程28个月);腔隙性中风35例(男26例,女9例,平均年龄67±11岁,平均病程26个月)。全部病例均经脑血管造影、颈动脉超声、CT和MRI证实,腔隙部位系位于底节、深部白质或脑干的小梗塞灶。
Serum lipoprotein (α) concentrations are genetically determined and are rarely affected by age, sex, nutritional or environmental factors such as medications, and ingestion restrictions. In order to explore the role of lipoprotein (α) in the pathogenesis of ischemic stroke, especially in young patients. The authors used advanced enzyme-linked immunosorbent assay to measure serum lipoprotein (α) concentrations in 101 patients with chronic ischemic stroke and 37 healthy controls. Combined with stroke type and age of onset. In 101 patients, 66 cases of arterial thrombotic stroke (44 males and 22 females, the average age of 60 ± 12 years, the average duration of 28 months); lacunar stroke in 35 cases (26 males and 9 females, mean Age 67 ± 11 years, the average duration of 26 months). All cases were diagnosed by cerebral angiography, carotid ultrasound, CT and MRI confirmed that the lacunar site is located in the bottom of the deep white matter or brain stem small infarction.