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文章阐述了内质网应激信号通路及其调控机制;补充了最新的调控通路;探讨了内质网应激与肿瘤发生和细胞凋亡的关系。同时将内质网信号通路全面概括到一张图中,综合阐述了未折叠蛋白反应(UPR)的调控机制,并把内质网应激与细胞凋亡、肿瘤发生关联到一起,方便读者更好地了解与学习内质网应激。
This article describes the endoplasmic reticulum stress signaling pathway and its regulatory mechanism; supplements the latest regulatory pathway; explores the relationship between endoplasmic reticulum stress and tumorigenesis and apoptosis. At the same time, the endoplasmic reticulum signal transduction pathway is fully summarized in a picture, which comprehensively expounds the regulatory mechanism of unfolded protein reaction (UPR) and correlates the endoplasmic reticulum stress with apoptosis and tumorigenesis so that the reader can better Understanding and learning endoplasmic reticulum stress.