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目的探讨氟喹诺酮类药物的抗菌活性。方法选取不同开发阶段的氟喹诺酮类药物:曲伐沙星,格帕沙星,莫西沙星,氧氟沙星,环丙沙星进行抗菌活性观察。结果新开发的氟喹诺酮类药物曲伐沙星、格帕沙星、阿拉曲沙星等对大部分革兰氏阴性菌的活性较强与以往氟喹诺酮类药物环丙沙星、氧氟沙星比较差异无统计学意义。结论新一代氟喹诺酮类药物曲伐沙星,格帕沙星,莫西沙星,对革兰氏阴性及阳性菌具有较强的抗菌活性,抗菌谱显著扩大,增加了临床应用范围。
Objective To investigate the antibacterial activity of fluoroquinolones. Methods Fluoroquinolones of different developmental stages were selected: trovafloxacin, grepafloxacin, moxifloxacin, ofloxacin and ciprofloxacin for antibacterial activity. Results The newly developed fluoroquinolones trovafloxacin, grepafloxacin and allatrofloxacin showed strong activity against most Gram-negative bacteria. Compared with the previous fluoroquinolones ciprofloxacin, ofloxacin The difference was not statistically significant. Conclusion The new generation of fluoroquinolones trovafloxacin, grepafloxacin and moxifloxacin have strong antibacterial activity against Gram-negative and positive bacteria, and the antibacterial spectrum is significantly enlarged, which increases the scope of clinical application.