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目的掌握本地区新生儿及婴幼儿TORCH感染情况及特点,为临床诊断及治疗提供依据。方法采用酶联免疫吸附试验检测患儿血清TORCH-IgM抗体,比较新生与婴幼儿抗体阳性率。结果 5920例患者中,TORCH-IgM阳性率为6.01%,新生儿和婴幼儿阳性率分别为3.40%和19.58%,以CMV阳性为主,且婴幼儿阳性率高于新生儿(P<0.01)。TORCH-IgM阳性患儿主要临床表现为肝炎综合征、病理性黄疸和肺炎。结论南宁地区新生儿及婴幼儿TORCH感染率较高,以CMV感染为主,且缺乏特异临床表现;加强高危人群TORCH筛查是降低出生缺陷发生率和减少患儿后遗症的有效措施,这对优生优育、提高人口素质具有重要意义。
Objective To understand the situation and characteristics of TORCH infection in newborns and infants in this area and provide the basis for clinical diagnosis and treatment. Methods Serum TORCH-IgM antibody was detected by enzyme-linked immunosorbent assay (ELISA), and the positive rate of antibody in neonates and infants was compared. Results The positive rate of TORCH-IgM was 6.01% in 5920 patients, 3.40% and 19.58% in newborns and infants, respectively. The positive rate of TORCH-IgM was mainly CMV, and the positive rate of TORCH-IgM was higher than that of newborns (P <0.01) . The main clinical manifestations of TORCH-IgM-positive children with hepatitis syndrome, pathological jaundice and pneumonia. Conclusion The prevalence of TORCH in neonates and infants in Nanning is high, with CMV infection as the mainstay and lacks specific clinical manifestations. TORCH screening in high-risk population is an effective measure to reduce the incidence of birth defects and reduce children’s sequelae. Excellent education and improving the quality of the population are of great significance.