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[目的]比较Corail羟基磷灰石(hydroxyapatite,HA)全涂层与骨水泥型股骨柄假体行全髋关节置换(total hip arthroplasty,THA)治疗高龄股骨颈骨折的早期临床疗效.[方法]回顾性分析2007年1月-2008年6月在重庆医科大学附属第一医院骨科THA治疗的54例单侧股骨颈骨折高龄患者的临床资料.根据股骨柄假体类型分为:HA组21例,全部采用Corail HA全涂层股骨柄假体;骨水泥组33例,采用Elite、Chamley骨水泥股骨柄假体.比较两组住院时间、手术时间、术中出血量、术中血流动力学参数变化、术后并发症、Harris评分以及放射学效果.[结果](1)HA组手术时间平均(52.6±7.2)min,术中出血平均(217.9±37.7)ml;骨水泥组手术时间平均(62.5±8.5)min,术中出血平均(250.2±57.3)ml.两组相比差异有统计学意义(P0.05).[结论]Corail HA全涂层股骨柄假体THA治疗高龄股骨颈骨折可取得与骨水泥股骨柄假体相似的早期临床疗效和放射学稳定性,并不会增加手术并发症,且可以缩短手术时间、减少术中出血,减少或消除骨水泥植入对患者心脏和外周血管的抑制作用,其中长期临床结果仍有待进一步研究.“,”[Objective]To compare the short-term clinical effect of Corail entirely hydroxyapatite (HA)-coated versus cemen-ted femoral stem prosthesis in total hip arthroplasty(THA) for elderly femoral neck fracture. [Method]Fifty-four cases of unilat-eral femoral neck fracture in patient over 75 were retrospectively analyzed from January 2007 to June 2008. In them,21cases un-derwent THA using Corail femoral prosthesis(HA group) ,and the other 33 were treated with cemented THA(cement group). The difference was compared in time of hospitalization, time of operation, blood loss, hemodynamic parameters, adverse effect, Harris scoring and radiological results. [Result](1) The average operation time were (52.6～7.2) minutes in HA group and (62.5 ±8.5) minutes in cement group, with significant difference (P < 0.05). The blood loss were (217.9± 37.7) ml in HA group and (250.2 ±57.3)ml in cement group, with significant differernce(P < 0.05). (2)At the moment when infusing the cement, the systolic blood pressure(SBP) and diastolic blood pressure(DBP) decreased significantly for 5～10 minutes,and recovered after 10 minutes. At 3 minutes after infusing the cement,the heart rate(HR) changed rapidly,and recovered after 5～20 minutes. But the hemodynamie parameters showed no significant change in HA group. (3)There were no significant statistical differences be-tween two groups in time of hospitalization, complications and radiographic evaluations(including radiolucent line, osteolysis, pros-thetie loosening and subsidence). [Conclusion]THA using Corail entirely HA-coated femoral stem prosthesis for treatment of elder patients with femoral neck fracture can be effectively performed without increased risk of complications. It has advantages of less operative time, blood loss and inhibition effect onmyocardial contraction and peripheral vascular function duringthe operation. Its short term result is satisfactory, but the me-dium and long term effection still need further research.