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围产期窒息是由多种原因引起的围产期急症,由此产生的严重低氧血症、酸中毒常造成多系统、多脏器损害。心血管系统的主要改变有心功能不全和暂时性房室瓣返流。近年发现,这些改变都与心内膜下心肌和乳头肌的损害有密切关系。病理生理在缺氧条件下,血流在体内发生重分布,即从肠道、肺和肾脏迅速向心、脑、肾上腺等重要脏器转移。据Shcldon等对羔羊的研究,围产期心肌正常血流量约为100ml/100g心肌/min,轻度缺氧时加倍;若缺氧严重(PaO_2:12～15torr),血流量可达625ml/100g心肌/
Perinatal asphyxia is caused by a variety of causes of perinatal emergency, resulting in severe hypoxemia, acidosis often result in multiple system, multiple organ damage. Major changes in the cardiovascular system have cardiac insufficiency and temporary atrioventricular valve regurgitation. In recent years, we found that these changes are closely related to the damage of the subendocardium and papillary muscles. Pathophysiology Under hypoxic conditions, blood flow redistributes in the body, that is, from the intestine, lungs and kidneys to the heart, brain, adrenal and other important organs metastasis. According to Shcldon’s study on lambs, perinatal myocardial blood flow is about 100ml / 100g myocardial / min, mild hypoxia doubled; if hypoxia (PaO_2: 12 ~ 15torr), blood flow up to 625ml / 100g Myocardium /