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探讨慢性前列腺炎(chronic prostatitis,CP)患者前列腺液(expressed prostatic secretion,EPS)中免疫球蛋白、细胞因子及趋化因子水平变化及它们在病理过程中的作用。将135例确诊的CP患者依据美国国立卫生研究院(NIH)制定的CP分类方法分为Ⅱ型(41例)、ⅢA型(50例)及ⅢB型(44例),另选40名体检合格的健康男性作为对照组。检测CP患者EPS中免疫球蛋白(IgG、IgM、IgA)、细胞因子(IL-1β、TNF-α、IL-6、IL-8、IL-10)及趋化因子(MCP-1、MIP-1α)水平,并与对照组检测结果比较。根据NIH-CP症状指数(NIH-CPSI)进行症状评分,分析各观察指标水平与症状严重程度的关系。(1)与健康人群比,CP患者EPS中各观察指标水平均明显升高(P<0.05)。(2)不同类型CP患者EPS中IL-1β、IL-8、MCP-1及MIP-1α水平高低趋势为:Ⅱ型>ⅢA型>ⅢB型(P<0.05);TNF-α、IL-6及IL-10水平在Ⅱ型、ⅢA型患者EPS中均明显高于ⅢB型(P<0.05),而在Ⅱ型与ⅢA型患者间无明显差异(P>0.05);3种类型患者间EPS中IgG、IgM及IgA水平均无明显差异(P>0.05)。(3)重度CP患者EPS中各观察指标水平均显著高于轻、中度患者(P<0.05);其中IL-6、IL-8、IL-10水平变化趋势为:重度>中度>轻度(P<0.05)。不同类型CP患者EPS中免疫球蛋白、细胞因子及趋化因子水平升高程度不同,其中IL-6、IL-8、IL-10水平与CP症状严重程度呈明显正相关。各观察指标水平检测有助于CP的诊断、分型以及疾病进展评估。
To investigate the changes of immunoglobulin, cytokines and chemokines in prostatic fluid (EPS) of patients with chronic prostatitis (CP) and their role in the pathological process. 135 cases of diagnosed CP patients were divided into type Ⅱ (41 cases), type ⅢA (50 cases) and type ⅢB (44 cases) according to the CP classification method of the National Institute of Health (NIH), 40 were eligible for physical examination Healthy male as control group. The levels of immunoglobulin (IgG, IgM, IgA), cytokines (IL-1β, TNF-α, IL-6, IL-8 and IL-10) and chemokines (MCP- 1α) levels, and compared with the control group test results. According to NIH-CP Symptom Index (NIH-CPSI) symptom score, analyze the relationship between the level of each indicator and the severity of symptoms. (1) Compared with healthy people, the levels of EPS in CP patients were significantly increased (P <0.05). (2) The levels of IL-1β, IL-8, MCP-1 and MIP-1α in EPS of EPS patients with different types of CP were higher and lower than those of patients with type Ⅱ> ⅢA> ⅢB (P <0.05) (P <0.05), but there was no significant difference between type Ⅱ and type ⅢA patients (P> 0.05). The levels of IL-10 and EPS in EPS of type Ⅱ and type ⅢA patients were significantly higher than that of type ⅢB The levels of IgG, IgM and IgA had no significant difference (P> 0.05). The levels of IL-6, IL-8 and IL-10 in severe CP patients were significantly higher than those in mild and moderate patients (P <0.05) Degrees (P <0.05). The levels of immunoglobulin, cytokines and chemokines in EPS of different types of CP patients were different, and the levels of IL-6, IL-8 and IL-10 were positively correlated with the severity of CP symptoms. The detection of various indicators of the level of CP contribute to the diagnosis, classification and assessment of disease progression.