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目的:研究痹祺胶囊对慢性坐骨神经压迫损伤(CCI)模型大鼠的镇痛作用。方法:SD大鼠,体质量180-220g,雌雄各半。随机分为假手术组,模型组,痹祺胶囊高、中、低剂量组,布洛芬组,每组10只。采用CCI模型。假手术组仅暴露坐骨神经,不结扎;痹祺胶囊高、中、低剂量组,布洛芬组于术后第3天起,连续12d,每天定时分别灌胃痹祺胶囊1.5、0.75、0.375g/kg,布洛芬0.5g/kg。假手术组和模型组以等体积0.9%氯化钠溶液灌胃。各组分别于术前,术后第3天、第7天、第14天测定热痛阈值。结果:与假手术组比较,模型组术后热痛阈降低(P<0.05)。与模型组和布洛芬组比较,痹祺胶囊高、中剂量组术后第3天、第7天、第14天时热痛阈升高(P<0.05)。结论:痹祺胶囊能提高神经病理性疼痛大鼠的热痛阈,具有明显的镇痛作用。
Objective: To study the analgesic effect of Biqi capsule on rats with chronic constriction injury (CCI). Methods: SD rats, body weight 180-220g, male and female half. Randomly divided into sham operation group, model group, Biqi Capsule high, medium and low dose group, ibuprofen group, 10 rats in each group. Using CCI model. The sham-operation group only exposed the sciatic nerve, not ligation; Biqi capsule high, medium and low dose group, ibuprofen group in the first 3 days after surgery, continuous 12d, respectively, time-daily gastric perfusion biqi capsule 1.5,0.75,0.375g / kg, ibuprofen 0.5g / kg. The sham operation group and model group were orally gavaged with 0.9% sodium chloride solution of equal volume. The pain thresholds were determined preoperatively, on the third day, the seventh day and the fourteenth day after operation. Results: Compared with the sham operation group, the pain threshold of the model group decreased after operation (P <0.05). Compared with the model group and the ibuprofen group, the pain thresholds of Biqi Capsule high and middle dose groups increased (P <0.05) on the 3rd, 7th and 14th day after operation. Conclusion: Biqi Capsule can increase the heat pain threshold in rats with neuropathic pain and has obvious analgesic effect.