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微流控混合器是微流控芯片的重要组成部分,是完成微量样品快速混合的一个功能部件。综述了国内外微流控混合器的最新研究进展,论述了微流控混合器的混合机理、设计方法、制作工艺、材料选择及应用等。微流控混合器分为主动式微流控混合器和被动式微流控混合器。主动式微流控混合器主要依靠外部力源实现微量样品的混合,如磁致微流控混合器、电极式微流控混合器和压电/超声波微流控混合器等。主动式微流控混合器结构复杂,因此不易与其他微流控功能器件集成。被动式微流控混合器制作工艺相对简单,易于集成,耗能低,应用广泛,已经在化学工程与生物工程中得到应用。
Microfluidic mixer is an important part of the microfluidic chip, is a complete micro-sample rapid mixing of a feature. The latest research progress of microfluidic mixers at home and abroad is reviewed. The mixing mechanism, design method, manufacturing process, material selection and application of microfluidic mixers are discussed. Microfluidic mixers are divided into active microfluidic mixers and passive microfluidic mixers. Active microfluidic mixers mainly rely on external force sources to achieve the mixing of trace samples such as magnetic microfluidic mixers, electrode-type microfluidic mixers and piezoelectric / ultrasonic microfluidic mixers. Active microfluidic mixers are complex and difficult to integrate with other microfluidic devices. Passive microfluidic mixer production process is relatively simple, easy to integrate, low energy consumption, widely used, has been applied in chemical engineering and bio-engineering.