目的探讨通过正畸修复联合治疗上颌前牙牙列缺损伴错牙合畸形的临床治疗效果。方法以随机数字法将2013年1月—2015年12月间杭州市第二人民医院收治的120例上颌前牙牙列缺损伴错牙合畸形患者随机分为2组,每组60例。对照组给予修复治疗,观察组给予正畸修复联合治疗。术后统计2组牙齿情况(咬合关系、牙齿排齐情况、前牙覆合覆盖率)、治疗效果、满意度、治疗费用及术后1年软垢指数和附着丧失指数。结果观察组咬合关系、牙齿排齐情况、前牙覆合覆盖率分别为80.0%、86.7%、93.3%,均明显高于对照组的61.7%、68.3%、75.0%,差异均有统计学意义(P<0.05)。观察组总有效率(93.3%)显著优于对照组(70.0%),差异有统计学意义(P<0.05)。观察组满意度和治疗费用分别为80.0%、(8 067.6±394.5)元,明显高于对照组的43.3%、(2 211.7±251.6)元,差异有统计学意义(P<0.05)。术后1年观察组软垢指数和附着丧失指数分别为0.13±0.08、5.16±1.42,显著低于对照组的0.66±0.17、6.49±1.63(P<0.05)。结论正畸修复联合治疗上颌前牙牙列缺损伴错牙合畸形疗效确切,可有效改善患者牙齿畸形、软垢指数和附着丧失指数,患者满意度高,但花费较高。 Objective To investigate the clinical effect of orthodontic treatment combined with maxillary anterior dentition denture malocclusion. Methods A total of 120 cases of maxillary anterior dentition defect accompanied with malocclusion were randomly divided into two groups (60 in each group) by random number method from January 2013 to December 2015 in Hangzhou Second People’s Hospital. The control group was given the repair treatment and the observation group was given the orthodontic repair combined treatment. Postoperative statistics of two groups of teeth (occlusal relationship, alignment of teeth, coverage of anterior teeth coverage), treatment effect, satisfaction, treatment costs and 1 year postoperative lurking index and attachment loss index. Results The occlusal relationship, dentition alignment and coverage of anterior teeth in the observation group were 80.0%, 86.7% and 93.3% respectively, which were significantly higher than that of the control group (61.7%, 68.3%, 75.0%), the differences were statistically significant (P <0.05). The total effective rate (93.3%) in the observation group was significantly better than that in the control group (70.0%), the difference was statistically significant (P <0.05). The satisfaction of the observation group and the cost of treatment were 80.0% (8 067.6 ± 394.5) yuan, significantly higher than that of the control group 43.3% (2 211.7 ± 251.6) yuan, the difference was statistically significant (P <0.05). At 1 year after operation, the fouling index and attachment loss index of the observation group were 0.13 ± 0.08 and 5.16 ± 1.42, respectively, which were significantly lower than those of the control group (0.66 ± 0.17 and 6.49 ± 1.63, P <0.05). Conclusion Orthodontic repair combined with the treatment of maxillary anterior dentition dentition defect with malocclusion is effective and can effectively improve the patients with dental malformations, soft dirt index and adhesion loss index, patients with high satisfaction, but higher cost.