论文部分内容阅读
目的:探讨狼疮性肾炎并急性肾衰的临床、病理特点及治疗措施。方法:收集符合狼疮性肾炎合并急性肾衰者共22例进行分析研究。结果:病人均属狼疮活动状态,肾脏病理改变以Ⅳ型较多见,与预后相关因素为大量蛋白尿、血清补体显著下降,肌酐清除率(Ccr)降低,累及脏器多少等。大剂量甲基强的松及环磷酰胺联合冲击治疗,总有效率为63.6%,死亡率为27.3%。结论:狼疮性肾炎并急性肾衰是肾科的危重症,而早期强有力的治疗可改善本病的预后。
Objective: To investigate the clinical, pathological features and treatment of lupus nephritis with acute renal failure. Methods: A total of 22 patients with lupus nephritis with acute renal failure were collected for analysis. Results: The patients were all lupus active. The pathological changes of kidney were more common in type Ⅳ. The factors associated with prognosis were massive proteinuria, significant decrease of serum complement, reduction of creatinine clearance (Ccr) and the number of involved organs. High-dose methyl prednisone and cyclophosphamide combined impact treatment, the total effective rate was 63.6%, the mortality rate was 27.3%. CONCLUSIONS: Lupus nephritis and acute renal failure are critically ill patients with nephrology. Early strong treatment may improve the prognosis of this disease.