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目的:观察胸腺切除对重症肌无力的影响。方法:采用ELISA法,对比了手术前后病人周围血中乙酰胆碱受体抗体及突触前膜受体抗体水平的变化。结果:伴发胸腺瘤的病者,乙酰胆碱受体抗体及突触前膜受体抗体水平高于伴发胸腺增生的病者;手术切除增生的胸腺可引起乙酰胆碱受体抗体水平的下降,而手术切除胸腺瘤可引起突触前膜受体抗体水平的增加。结论:术后周围血中抗PsmRAb水平增加,机制有待研究。
Objective: To observe the effect of thymectomy on myasthenia gravis. Methods: The levels of acetylcholine receptor antibody and presynaptic membrane receptor antibody in peripheral blood of patients before and after surgery were compared by ELISA. Results: Patients with thymoma, antibodies to AChR and antibodies to presynaptic membrane receptors were higher than those with thymic hyperplasia. Surgical removal of proliferative thymus caused a decrease in antibody levels to acetylcholine receptors, whereas surgery Excision of thymoma can cause an increase in presynaptic membrane receptor antibody levels. Conclusion: The anti-PsmRAb level in the peripheral blood increases after the operation, and the mechanism remains to be studied.