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目的:观察银杏达莫注射液对糖尿病肾病(DN)患者的临床疗效。方法:将168例DN患者随机分为对照组和治疗组各84例,对照组与治疗组均采用包括健康教育、医学营养治疗、体育锻炼及常规胰岛素降血糖治疗;治疗组在此基础上应用银杏达莫注射液20mL,用0.9%氯化钠注射液稀释成250mL,静脉滴注,l次/d。两组患者均治疗14d为l疗程,治疗3个疗程后进行效果评价,测定分析血液流变学及生化相关指标:包括高切黏度、低切黏度、血沉及血浆黏度;血清尿素氮(BUN)、肌酐(SCr)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-c)及高密度脂蛋白胆固醇(HDL-c);24h尿白蛋白定量(UAlb);同时测定治疗前后的空腹血糖(FPG)和餐后2h血糖(2hPG)。结果:治疗后两组的FPG和2hPG均有明显下降,治疗前后比较差异有统计学意义(P<0.05),但两组间比较差异无统计学意义(P>0.05)。治疗后两组的UAlb、TC、TG、LDL-c、高切黏度、低切黏度、血沉和血浆黏度均有显著性下降,HDL-c显著性上升,差异有统计学意义(P<0.05),但治疗组改变更明显,两组间比较差异有统计学意义(P<0.05)。两组患者治疗前后BUN、Scr无明显变化(P>0.05)。结论:银杏达莫注射液能明显降低糖尿病肾病患者的血脂水平,改善血液黏度,减少蛋白尿,临床疗效显著。
Objective: To observe the clinical effect of Yinxingdamo injection on patients with diabetic nephropathy (DN). Methods: A total of 168 patients with DN were randomly divided into control group and treatment group, 84 cases each. The control group and treatment group were treated with health education, medical nutrition therapy, physical exercise and conventional insulin hypoglycemic therapy. The treatment group was based on this Ginkgo biloba injection 20mL, 0.9% sodium chloride injection diluted to 250mL, intravenous infusion, l times / d. Two groups of patients were treated for 1d course of treatment for 1d after 3 courses of treatment for the evaluation of the effect of blood rheology and biochemical indicators were measured: high shear viscosity, low shear viscosity, erythrocyte sedimentation rate and plasma viscosity; serum urea nitrogen (BUN) SCr, TC, LDL-c and HDL-c; 24-hour urinary albumin (UAb); Fasting blood glucose (FPG) and 2h postprandial blood glucose (2hPG) were measured before and after treatment. Results: FPG and 2hPG in both groups were significantly decreased after treatment, with significant difference before and after treatment (P <0.05), but there was no significant difference between the two groups (P> 0.05). After treatment, the levels of UAlb, TC, TG, LDL-c, high shear viscosity, low shear viscosity, erythrocyte sedimentation rate and plasma viscosity decreased significantly and HDL-c significantly increased in the two groups (P 0.05) , But the treatment group changed more obviously, the difference between the two groups was statistically significant (P <0.05). Before and after treatment, BUN and Scr showed no significant changes in both groups (P> 0.05). Conclusion: Yinxingdamo injection can significantly reduce the level of serum lipids in patients with diabetic nephropathy, improve blood viscosity and reduce proteinuria, with a significant clinical effect.